At Internet scale (~2 billion connected users) it's minuscule.
0.005% of all available users.
Within the United States, it would fall well below the 100th most widely circulated print magazine, as a monthly circulation statistic. I'll assume that monthly stats are a few times higher than the daily usage metric, but you'd still have to hit roughly 1 million to break into the top 100.
https://en.wikipedia.org/wiki/List_of_magazines_by_circulati...
From an advertising perspective, unless you're extremely focused in your interest base (and there are markets of interest within the HN readership), it's tiny.
50 to 100 thousand daily users ("users", not visitors) is not small by any means!